Dehydration Cognition

Dehydration Clinical Trial

Official title:

Impact of Dehydration and Rapid Rehydration on Cognitive Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05916183
• Other study ID #: STUDY00007342
• Status: Completed
• Phase: N/A
• Start date: July 5, 2023
• Est. completion date: December 22, 2023

Study information

• Verified date: March 2024
• Source: State University of New York at Buffalo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators want to understand the impact of the body losing and gaining water on brain function. Participants will restrict fluids consumed and exercise to lose 5% of body mass. Participants will then be provided fluid equal to the volume lost to consume over 2 hours (recovery). A series of brain function tests will be performed at baseline, following weight loss, and following recovery.

Description:

A baseline series of brain function tests will be performed. Following this, participants will complete a 24 hour fluid and water rich food restriction on the day proceeding testing. Participants will then complete moderate to high intensity exercise in a hot/humid room to achieve 5% body mass loss. Once baseline core body temperature returns to baseline levels, the series of brain function tests will be performed. Participants will then consume a sports drink equal to the volume of sweat lost over the course of a 2 hour recover period. Following this, he series of brain function tests will be performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: December 22, 2023
• Est. primary completion date: December 22, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 26 Years

Eligibility

Inclusion Criteria:

• Healthy
• Recreationally active
• 18-26 years old

Exclusion Criteria:

• History of cardiovascular, metabolic, respiratory, neural, or renal disease
• Hypertensive (systolic blood pressure = 140 mmHg, diastolic blood pressure = 90 mmHg) or tachycardic (resting heart rate = 100 bpm) during the screening visit
• Taking medication or supplements with a known side effect of affecting physiological responses to exercise (e.g., aspirin, acetaminophen, beta blockers, statins, stimulants, depressants, SSRIs)
• Tobacco or nicotine use in the past six months
• Current or past musculoskeletal injury impacting physical activity
• Study physician discretion based on any other medical condition or medication

Related Conditions & MeSH terms

• Dehydration

Intervention

Behavioral:
• Fluid loss and consumption
Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period

Locations

Country	Name	City	State
United States	University at Buffalo	Buffalo	New York

Sponsors (1)

Lead Sponsor	Collaborator
State University of New York at Buffalo

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Multitasking test	Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome	Upon completion of 5% body mass loss protocol, approximately 2 hours into the trial
Primary	Multitasking test	Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome	2 hours following the dehydration cognitive function test, approximately 4.5 hours into the trial