Fluid Therapy Clinical Trial
Official title:
Intravenous Hydration After Surgery Using Boluses of Balanced Salt Solution
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar. The basic tenets include: (1) Continuous intravenous fluid administration; (2) Total fluid volume based on the "4:2:1" rule; (3) Use of hypotonic electrolyte solutions, most commonly 0.45% sodium chloride (NaCl) + 20 milliequivalents per liter (mEq/L) potassium chloride (KCl); and (4) Inclusion of 5% dextrose to increase the osmolarity of the infusate and to help prevent ketosis and acidemia.
Recent studies have questioned the validity of each of these tenets. Maintenance rate as defined by Holliday & Segar is postulated to be in excess of pediatric patients' post-surgical fluid needs. The investigators propose a novel protocol for the administration of IV fluids to children after major abdominal or thoracic surgery that includes: (1) Intermittent boluses; (2) Total volume administered in 24 hours closer to 2/3 of the traditional maintenance fluid requirements; and (3) Use of a balanced salt solution (Lactated Ringer). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT06351475 -
Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
|
N/A | |
| Not yet recruiting |
NCT04982016 -
Effects of Fluid Therapy on Microcirculatory Reactivity
|
N/A | |
| Completed |
NCT03215797 -
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
|
Phase 3 | |
| Completed |
NCT04536324 -
The Absorption Rate of Subcutaneous Infused Fluid
|
||
| Completed |
NCT02977390 -
Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM
|
N/A | |
| Recruiting |
NCT01415284 -
ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia
|
Phase 4 | |
| Completed |
NCT03245372 -
Goal Directed Therapy Versus Standard Care in Lung Resection Surgery (GDT-thorax Study).
|
N/A | |
| Recruiting |
NCT05606536 -
The Impact of Intra-operative Fluid Infusion Rate on Microcirculation
|
N/A | |
| Terminated |
NCT03553394 -
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
|
N/A | |
| Recruiting |
NCT05153837 -
Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers
|
N/A | |
| Completed |
NCT03323580 -
Effects of Intraoperative GDFT on the Postoperative Brain Edema
|
N/A | |
| Completed |
NCT03394833 -
Hemodynamic Stability During Induction of Anaesthesia
|
N/A | |
| Completed |
NCT03280953 -
Assessing Fluid Responsiveness With PWTT
|
||
| Recruiting |
NCT03178578 -
A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy
|
||
| Enrolling by invitation |
NCT04388995 -
SVV and PPV Predict Fluid Responsiveness in Mechanically Ventilated Elderly Patients Under General Anesthesia
|
N/A | |
| Not yet recruiting |
NCT06396884 -
Hemodynamic Optimization During Spinal Anesthesia in the Elderly
|
||
| Recruiting |
NCT05369559 -
Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department
|
Early Phase 1 | |
| Recruiting |
NCT05054452 -
Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocardiography
|
N/A | |
| Completed |
NCT03060408 -
Comparison of Fluid Requirements in Pancreatectomy: Laparotomy vs. Laparoscopy
|
N/A | |
| Completed |
NCT00500981 -
Internal Jugular Vein Ultrasound Measures and Fluid Responsiveness in Post-Operative Cardiac Surgical Patients
|
Phase 1 |