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Dehydration in Children clinical trials

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NCT ID: NCT05285371 Active, not recruiting - Fluid Therapy Clinical Trials

Boluses of Ringer's in Surgical Kids (BRiSK Study)

BRiSK
Start date: February 22, 2022
Phase: Early Phase 1
Study type: Interventional

Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar. The basic tenets include: (1) Continuous intravenous fluid administration; (2) Total fluid volume based on the "4:2:1" rule; (3) Use of hypotonic electrolyte solutions, most commonly 0.45% sodium chloride (NaCl) + 20 milliequivalents per liter (mEq/L) potassium chloride (KCl); and (4) Inclusion of 5% dextrose to increase the osmolarity of the infusate and to help prevent ketosis and acidemia.