Degenerative Spondylolisthesis Clinical Trial
Official title:
Short-term Clinical Outcome of Cortical Bone Trajectory Compared With the Traditional "Open" and Minimal Invasive Posterior Lumbar Interbody Fusion
A combined prospective cohort study and retrospective analysis of previously collected data. Three different techniques for posterior lumbar interbody fusion (PLIF) are compared: CBT-PLIF, MI-PLIF and open PLIF. A total of 180 patients are included, who will be followed up to 6 weeks postoperatively.
A combined prospective cohort study for CBT-PLIF and retrospective analysis of prospectively collected data from the MISOS study, regarding traditional open PLIF and MI-PLIF. A total of 180 patients will be included in the study: 60 prospective CBT-PLIF patients, 60 retrospective open PLIF patients and 60 retrospective MI-PLIF patients. The new data will be collected prospectively by means of questionnaires. No biomaterial will be collected. The included patients will be asked to complete questionnaires before surgery, 2 and 6 weeks after surgery. In addition, VAS scores will be noted throughout the hospital stay, 2 and 6 weeks after surgery. Inclusion criteria: Patients aged 18-75 years with neurogenic claudication and/or radicular leg pain due to low-grade (Meyerding grades l and ll) degenerative or spondylolytic spondylolisthesis with persistent symptoms for more than 3 months. Exclusion criteria: previous spinal fusion surgery at the same level, osteoporosis (only when using bisphosphonate), active infection or previous infection at the surgical site, active cancer, spondylolisthesis grade III or greater, more than one symptomatic level requiring fusion, pregnancy, contraindication to surgery, severe mental or psychiatric disorder, substance abuse, insufficient knowledge of the Dutch language and morbid obesity (body mass index >40). Main research question: Does the CBT-PLIF provide less low back pain in the short term than the traditional open PLIF and the MI-PLIF? Primary outcome measure - Low back pain measured with the Visual Analogue Scale (VAS) 2 weeks after surgery Secondary Outcomes - Low back pain during hospitalization (measured every day), 2 and 6 weeks after surgery - Leg pain - Oswestry Disability Index - Quality of life (EQ-5D-5L) - Observed patient recovery - Other parameters such as complications, surgical parameters (intraoperative blood loss, duration of surgery), length of stay in hospital and return to work ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05114135 -
TLIF Osteo3 ZP Putty Study (Also Known as the TOP Fusion Study)
|
N/A | |
Recruiting |
NCT04378543 -
Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion
|
Phase 1/Phase 2 | |
Withdrawn |
NCT03223701 -
Efficacy of Using Solum IV and BMC With GFC in TLIF
|
Phase 4 | |
Not yet recruiting |
NCT06000319 -
Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion
|
||
Completed |
NCT00996073 -
Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion
|
Phase 2 | |
Withdrawn |
NCT02530775 -
"Is Instrumentation Necessary for "Static" Degenerative Spondylolisthesis"
|
N/A | |
Terminated |
NCT03570801 -
SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion
|
N/A | |
Enrolling by invitation |
NCT04418830 -
Lumbar Interbody Implant Study
|
||
Completed |
NCT03303300 -
The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy
|
N/A | |
Withdrawn |
NCT00810212 -
Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion
|
Phase 1/Phase 2 | |
Terminated |
NCT04483297 -
First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS)
|
Phase 1 | |
Completed |
NCT03898232 -
Fibergraft Interbody Fusion Retrospective
|
||
Completed |
NCT00726310 -
Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal Instability
|
||
Recruiting |
NCT06154005 -
OsteoAdapt SP Advanced Bone Graft Feasibility Study - Transforaminal Interbody Lumbar Fusion
|
Phase 1/Phase 2 | |
Completed |
NCT04418817 -
Modulus in XLIF Study
|
||
Completed |
NCT02087267 -
Lumbar Fusion With The Icotec CF/PEEK Pedicle System In Combination With The Icotec CF/PEEK TLIF Cage ETurn™
|
||
Terminated |
NCT01528072 -
Dynesys Spinal System Post Market 522 Study
|
N/A | |
Active, not recruiting |
NCT03733626 -
Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease
|
N/A | |
Active, not recruiting |
NCT05993195 -
Re-operation Rates of Concorde Bullet Device Versus Conduit Titanium Interbody Graft for Lumbar Fusion
|
||
Recruiting |
NCT06394089 -
Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol
|