Degenerative Disc Disease Clinical Trial
Official title:
Advanced MR Imaging in Patients With Painful, Degenerative Disc Disease: A Pilot Study
In this study, we will use advanced and newly available MR imaging techniques at 3 Tesla
(including in situ axial loading and quantitative T1rho, T2, and diffusion measurements) to
assess the intervertebral discs and adjacent vertebrae in patients with lumbar back pain
scheduled for back surgery (n=20), patients with degenerative disease without classic
discogenic back pain (n=10), patients who had discectomies for herniated discs (n=5), and
age-matched volunteers without back pain (n=10). In all patients standard imaging procedures
will also be performed, including radiographs, standard MRI at 1.5 Tesla and discography.
All patients will have specimen of the intervertebral disc harvested at surgery and
pathologic analysis and spectroscopy of these specimen will be performed. Post-surgical
findings/outcome combined with discography will serve as a standard of reference for the
identification of the painful disc(s). The diagnostic performance of the new techniques in
assessing the painful disc will be evaluated. We will collect disc specimens from 50
patients undergoing back surgery but did not have pre-surgical MR imaging. These disc
specimens will be analyzed in the same manner as the specimens collected from surgical
patients who had pre-surgical MRI. This study will serve as a pilot study for a larger
project focusing on advanced imaging of the painful intervertebral disc.
We hypothesis that advanced, dedicated MR examinations at 3T can identify painful
degenerated discs in patients with chronic lumbar back pain.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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