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Deficiency Diseases Vitamin clinical trials

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NCT ID: NCT04170348 Active, not recruiting - Asthma Clinical Trials

Daily Vitamin D for Sickle-cell Respiratory Complications

ViDAS-2
Start date: September 15, 2020
Phase: Phase 2
Study type: Interventional

This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease. Respiratory problems are the leading causes of sickness and of death in sickle cell disease. The investigators hypothesize that daily oral vitamin D3, compared to monthly oral vitamin D, will rapidly increase circulating vitamin D3, and reduce the rate of respiratory complications by 50% or more within the first year of supplementation in children and adolescents with sickle cell disease. This study is funded by the FDA Office of Orphan Products Development (OOPD).