Respiration, Artificial Clinical Trial
Official title:
Fluid Leakage Past Tracheal Tube Cuff : Effect of Suctioning Manoeuvre
The leakage of oropharyngeal secretions around high-volume low-pressure tracheal tube cuffs is usually considered as a major risk factor for bacterial tracheal colonization and subsequent development of ventilator-associated pneumonia. The rate of leakage around the cuff is related to the pressure differential across the cuff, namely the difference between the pressure of the subglottic fluid above the cuff and the tracheal pressure under the cuff. Consequently, positive end-expiratory pressure (PEEP) improves the sealing around the cuff towards fluid leakage. However, this preventive effect of PEEP is compromised during prolonged mechanical ventilation by tracheal suctioning manoeuvre, which may enhance fluid leakage, by decreasing tracheal pressure. Indeed, in a benchtop model, a suctioning manoeuvre, without disconnection of the ventilator, induced a constant fluid leakage past a high-volume low-pressure tracheal tube cuff when performed with a high level of suction pressure (- 400 mbar) and a large size of suction catheter size (16 French).
This clinical study aims to confirm these experimental data in patients under mechanical ventilation. ;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04107467 -
Mechanical Ventilation Epidemiology in Argentina.
|
||
Recruiting |
NCT03181620 -
Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation
|
N/A | |
Recruiting |
NCT03941002 -
Continuous Evaluation of Diaphragm Function
|
N/A | |
Recruiting |
NCT03697785 -
Weaning Algorithm for Mechanical VEntilation
|
N/A | |
Recruiting |
NCT05459116 -
Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
|
N/A | |
Recruiting |
NCT05141396 -
Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)
|
N/A | |
Completed |
NCT04512677 -
Ventilatory Weaning Guided by a New Index
|
N/A | |
Withdrawn |
NCT00536445 -
Use of NAVA in Intubated Preterm
|
Phase 1/Phase 2 | |
Completed |
NCT00097630 -
ABC Trial: Awakening and Breathing Controlled
|
N/A | |
Recruiting |
NCT04602182 -
Effectiveness of Musicotherapy in Weaning From Mechanical Ventilation
|
N/A | |
Recruiting |
NCT06120660 -
Musical Intervention on Stress Effects in Critically Ill Patients
|
N/A | |
Active, not recruiting |
NCT04023643 -
Pediatric Ventilation Weaning
|
N/A | |
Recruiting |
NCT03684291 -
Hemodynamic Effects of Ventilation Modes
|
||
Recruiting |
NCT06195475 -
Association Between Tidal Volume and Mortality in Pressure Support in Adults Under Invasive Mechanical Ventilation
|
||
Completed |
NCT05254691 -
WOB and Paediatric Mechanical Ventilation
|
N/A | |
Terminated |
NCT00790725 -
Proportional Assist Ventilation vs Pressure Support Ventilation
|
N/A | |
Completed |
NCT00638339 -
Effects Of Invasive And Noninvasive Mechanical Ventilation On Sleep In The Intensive Care Unit (ICU)
|
||
Not yet recruiting |
NCT03255356 -
Ventilation in Cardiac Surgery
|
N/A | |
Completed |
NCT01155648 -
Pressure Support During Chest Wall Compression
|
N/A | |
Completed |
NCT00583037 -
24-Hour NAVA Ventilation in Acute Respiratory Failure
|
N/A |