Interactions of Brain Regions in Visuomotor Adaptation

Deep Brain Stimulation Clinical Trial

Official title:

Functional Interaction of Thalamus, Basal Ganglia, and the Cerebellum in Visuomotor Adaptation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04190940
• Other study ID #: 21483
• Status: Recruiting
• Phase: N/A
• Start date: April 18, 2019
• Est. completion date: April 17, 2021

Study information

• Verified date: December 2019
• Source: University of Virginia
• Contact: Sarah Adams
• Phone: 4342434319
• Email: neuromodlab[@]hscmail.mcc.virginia.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation procedure to their thalamus as a part of their medical procedure. Participation in this study will include completing a behavioral task before and after the procedure to see how motor learning task performance differs with and without the thalamus. Similarly, patients undergoing Deep Brain Stimulation (DBS) treatment will have an electrode implanted in their thalamus as a part of their medical procedures. Participation in this study will include completing the motor learning task performance "on" and "off" thalamic electrical stimulation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 39
• Est. completion date: April 17, 2021
• Est. primary completion date: April 17, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• Be a patient receiving either high intensity focused ultrasound treatment or deep brain stimulation treatment for Tremor

• Able to provide informed consent and complete study procedures

• Must speak English

• Age 18-85

Exclusion Criteria:

• Not receiving one of the specified inclusion criteria

• Unable to provide consent or complete study procedures

• Women who self-report pregnancy

• Patients who are currently incarcerated

Related Conditions & MeSH terms

• Deep Brain Stimulation
• High Intensity Focused Ultrasound

Intervention

Behavioral:
• Behavioral Assessment
Patients will be asked to complete the behavioral assessment before and after their HIFU treatment or "on" and "off" their DBS treatment.

Locations

Country	Name	City	State
United States	University of Virginia	Charlottesville	Virginia

Sponsors (1)

Lead Sponsor	Collaborator
University of Virginia

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Performance Error on Visuomotor Task	The visuomotor task has practice, baseline, and experimental trials. Performance on the task will be compared between groups (HIFU treatment and DBS treatment) before and after treatment.	baseline, a week after HIFU treatment, several weeks after DBS implantation