Morphine Gel for Bedsores

Decubitus Ulcer Clinical Trial

Official title: Morphine-Infused Gel for Pressure Ulcer Analgesia

Status Completed

Clinical Trial Summary

This study tests the effectiveness of a morphine-containing gel for reducing pain caused by pressure ulcers, also known as bedsores or pressure sores. We will apply the gel containing morphine, or the gel alone, directly onto painful pressure ulcers and compare the results.

Clinical Trial Description

In this study, we will apply a morphine-containing gel (or placebo) directly onto painful pressure ulcers. We will take participants off of any opioid-containing medications upon entry into the study. This allows us to measure any morphine that may enter into the bloodstream from the topically applied gel.

The purpose of this study is to examine the efficacy of the gel for pressure ulcer analgesia, as well as the systemic absorption of morphine from the topically applied gel. We will document the amount of pain medications taken by participants to determine whether the gel decreases the need for these drugs. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Decubitus Ulcer
• Pressure Ulcer

• NCT number: NCT00007254
• Study type: Interventional
• Source: University of Kansas Medical Center
• Status: Completed
• Phase: Phase 1/Phase 2
• Start date: March 2000
• Completion date: February 2003