High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

Decompression Sickness Clinical Trial

Official title:

High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02064361
• Other study ID #: SCUBACYC
• Status: Completed
• Phase: N/A
• First received: February 12, 2014
• Last updated: February 13, 2014
• Start date: February 2013
• Est. completion date: May 2013

Study information

• Verified date: February 2014
• Source: University of Split
• Contact: n/a
• Is FDA regulated: No
• Health authority: Croatia: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving. Outcomes are determined by the quantification and subtype of circulating microparticles, complete blood counts, and the quantification of venous gas emboli, measured via transthoracic echocardiography, in the cardiac cavities.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: May 2013
• Est. primary completion date: May 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Experienced divers (> 250 logged dives)

• Male

• Physician clearance to dive

Exclusion Criteria:

• Prior incidence of decompression sickness

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Decompression Sickness
• SCUBA Diving

Intervention

Other:
• High intensity exercise
Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.

Locations

Country	Name	City	State
Croatia	University of Split School of Medicine	Split	Dalmatia
United States	University of Maryland	Baltimore	Maryland

Sponsors (2)

Lead Sponsor	Collaborator
University of Split	University of Maryland

Countries where clinical trial is conducted

United States,  Croatia, 

References & Publications (1)

Thom SR, Milovanova TN, Bogush M, Yang M, Bhopale VM, Pollock NW, Ljubkovic M, Denoble P, Madden D, Lozo M, Dujic Z. Bubbles, microparticles, and neutrophil activation: changes with exercise level and breathing gas during open-water SCUBA diving. J Appl Physiol (1985). 2013 May 15;114(10):1396-405. doi: 10.1152/japplphysiol.00106.2013. Epub 2013 Mar 14. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline values of number of circulating microparticles per microliter of blood		Prior to exercise, prior to diving, 15 and 120 minutes after surfacing	No