Aortic Stiffness in Chronic Kidney Disease Stage 2 to 4

Decline in Renal Function Clinical Trial

Official title:

Evaluation of Aortic Stiffness in CKD II to IV

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01279460
• Other study ID #: Munich-CKD-PWA
• Status: Completed
• Phase: N/A
• First received: January 17, 2011
• Last updated: January 17, 2011
• Start date: October 2007
• Est. completion date: December 2010

Study information

• Verified date: January 2011
• Source: Technische Universität München
• Contact: n/a
• Is FDA regulated: No
• Health authority: Ethikkommission der Fakultät für Medizin der Technischen Universität München, Germany:
• Study type: Observational

Clinical Trial Summary

This study aimed to investigate in a cohort with chronic kidney disease the longitudinal relationship between aortic stiffness and renal function and mortality.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 167
• Est. completion date: December 2010
• Est. primary completion date: December 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age 18 or older

• CKD 2-4

Exclusion Criteria:

• pregnancy

• history of malignant disease with a prognostic life expectancy less than 24 months

• missing of written and informed consent

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Decline in Renal Function
• Renal Insufficiency, Chronic

Locations

Country	Name	City	State
Germany	Klinikum rechts der Isar	München	Bavaria
Germany	Klinikum Weissenburg	Weissenburg	Bavaria

Sponsors (2)

Lead Sponsor	Collaborator
Technische Universität München	Department of Nephrology, Klinikum rechts der Isar, München

Country where clinical trial is conducted

Germany, 

References & Publications (2)

Pan CR, Roos M, Schmaderer C, Lutz J, Wang JG, Heemann U, Baumann M. Interrelationship between aortic stiffness and proteinuria in chronic kidney disease. J Hum Hypertens. 2010 Sep;24(9):593-9. doi: 10.1038/jhh.2009.108. Epub 2010 Jan 28. — View Citation

Townsend RR, Wimmer NJ, Chirinos JA, Parsa A, Weir M, Perumal K, Lash JP, Chen J, Steigerwalt SP, Flack J, Go AS, Rafey M, Rahman M, Sheridan A, Gadegbeku CA, Robinson NA, Joffe M. Aortic PWV in chronic kidney disease: a CRIC ancillary study. Am J Hypertens. 2010 Mar;23(3):282-9. doi: 10.1038/ajh.2009.240. Epub 2009 Dec 17. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	combined renal end-point (>25% decline in renal function or start of renal replacement therapy)		24 months	No
Secondary	mortality		24 months	No