Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt

Decay, Dental Clinical Trial

Official title:

Effect of Propolis and Pomegranate Extract Mouthwash on Taste Alteration, Salivary pH and Antibacterial Activity in High Caries Risk Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03623048
• Other study ID #: CEBD-CU-2018-08-04
• Status: Not yet recruiting
• Phase: N/A
• Start date: March 2019
• Est. completion date: April 2019

Study information

• Verified date: September 2018
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Description:

This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 80
• Est. completion date: April 2019
• Est. primary completion date: April 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 17 Years to 50 Years

Eligibility

Inclusion Criteria:

• High caries risk patients defined according to American Dental Association (ADA)

• Systematically healthy

• Not taking any medication interfering with saliva secretion

• Subjects who signed informed consent

• Age range from 17-50 years

Exclusion Criteria:

• Subjects suffering from any medical or systematic disease

• Smokers

• Pregnant females

• Allergy to any of the mouthwash ingredients

• Patients older than 50 years

Related Conditions & MeSH terms

• Decay, Dental
• Dental Caries

Intervention

Other:
• chlorhexidine
antibacterial and anti-inflammatory mouthwash
• saline
anti-inflammatory cleansing mouthwash
• Propolis extract
antibacterial mouthwash
• pomegranate extract
antibacterial mouthwash

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Taste alteration	taste changes will be measured by a questionnaire	One week
Secondary	Salivary pH	salivary pH will be measured by digital pH meter	one week