Effects on the Scalp Lipids and TEWL of a 1% Selenium Disulfide and 1% Salicylic Acid Antidandruff Shampoo on Dandruff Scalp

Dandruff Clinical Trial

Official title: Evaluation of the Antidandruff Effect of a Shampoo on Subjects With Dandruff and Slight Itching. Single-blind, Monocentric Study Realized Under Dermatological Control

Status Not yet recruiting

Clinical Trial Summary

The aim of this study was to investigate the changes in the scalp lipids and TEWL in dandruff subjects treated by 1% Selenium Disulfide (SeS2)/1% salicylic acid-based shampoo after an antidandruff treatment and after a remanence phase

Clinical Trial Description

Dandruf often has a substantial negative impact on quality of life. The proliferation of Malassezia specie has been shown to be linked to dandruff. Yet, the sebum is essential for the growth of Malassezia restricta. The sebum is mainly constituted by waxes, squalene and triglycerides. The triglycerides are partially transformed in free fatty acids while the squalene can be oxidized. Therefore, the change in lipids can be of interest for dandruff studies. The scalp barrier function of a dandruff scalp is known to be altered and must recover after an antidandruff treatment The aim of this study is to investigate the change of the scalp lipids and TEWL after a 1% selenium disulfide and 1% salicylic acid antidandruff shampoo on dandruff scalp and after a remanence period ;

Related Conditions & MeSH terms

• Dandruff

• NCT number: NCT05503706
• Study type: Interventional
• Source: L'Oreal
• Contact: Philippe MASSIOT, pHD
• Phone: 0660992467
• Email: philippe.massiot@rd.loreal.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 2022
• Completion date: December 2022