Dacryocystitis Clinical Trial
Official title:
Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis
To assess the efficacy and safety of local application of intraoperative mitomycin C (MMC) at osteotomy site in endoscopic dacryocystorhinostomy(EN-DCR).
Mitomycin C (MMC) is an antineoplastic agent that inhibits the synthesis of DNA, cellular
RNA, and protein by inhibiting the synthesis of collagen by fibroblasts. MMC was originally
used as a systemic chemotherapeutic agent, it has been widely used in ophthalmic practice
both intraoperatively and postoperatively for prevention of pterygium recurrence, enhancing
the success rate of glaucoma filtration surgery. Recently, use of MMC has been described in
lacrimal drainage surgery. It is postulated that adjunctive use of MMC over the osteotomy
site in endoscopic dacryocystorhinostomy(EN-DCR)surgery could inhibit scarring and
granulation tissue formation around the osteotomy site or common canaliculus and enhance the
success of EN-DCR surgery.
Many controlled trials have investigated adjunctive MMC for primary or revision EN-DCR to
augment the surgical success rate, but the results are not completely consistent. To the
best of our knowledge, there was no meta-analysis on comparison of success rate of EN-DCR
with MMC (MMC group) and endoscopic dacryocystorhinostomy without MMC (control group).
Therefore, the aim of this study was to undertake systematic review and meta-analysis to
evaluate the efficacy of intraoperative MMC application in EN-DCR surgery and help
ophthalmologists to determine whether it is a useful adjuvant in EN-DCR surgery.
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Observational Model: Case Control, Time Perspective: Retrospective
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