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Effect of Antioxidant Docosahexaenoic Acid (DHA) in Cystic Fibrosis Patients

Cystic Fibrosis in Children Clinical Trial

Official title:
Effect of Antioxidant Docosahexaenoic Acid (DHA) Supplementation in Cystic Fibrosis Patients: A Randomized Placebo-controlled Trial

Clinical Trial Summary

This study evaluates the effect of antioxidant docosahexaenoic acid (DHA) in patients with cystic fibrosis. Half of participants will receive DHA, while the other half will receive placebo.

Clinical Trial Description

Several studies show that patients with cystic fibrosis (CF) usually have, compared to the normal population, low levels of linoleic acid (LA) and docosahexaenoic acid (DHA) and increase in arachidonic acid (AA), which is pro-inflammatory. Normalization or modification of this fatty acid pattern (AP) could reduce chronic inflammation. The aim of this study is to assess the effect of oral supplementation with DHA for one year in pediatric patients (6-18 years) with CF, on inflammatory parameters, AP profile, lung function (spirometry) and number of exacerbations. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04987567
Study type Interventional
Source Corporacion Parc Tauli
Contact
Status Completed
Phase N/A
Start date March 21, 2018
Completion date February 20, 2020
View Details
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