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Clinical Trial Summary

In cystic fibrosis (CF) renal base excretion is impaired, due to mutations in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene, since CFTR function is crucial in regulation of the kidney's HCO3- excretion. The investigators suggest that challenged urine HCO3- excretion is a biomarker of CFTR function, which can be used to evaluate the extent of CFTR dysfunction and the possible correcting effects of CFTR modulating therapy. This study aims to evaluate changes in challenged urine HCO3- excretion in CF patients, who are currently in treatment with the triple CFTR modulator combination therapy, Elexacaftor/tezacaftor/ivacaftor (ETI), before, during, and after a short treatment pause.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05818319
Study type Interventional
Source University of Aarhus
Contact Amalie Q. Rousing, BM
Email arousing@biomed.au.dk
Status Recruiting
Phase N/A
Start date June 1, 2023
Completion date December 2023

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