Clinical Trials Logo

Clinical Trial Summary

Introduction : The most common technique used for ovarian cystectomy is the stripping technique. After stripping the cyst wall, the subsequent bleeding of the ovarian stromal wound is usually controlled by bipolar coagulation or/and by suturing. However, hemostasis achieved with bipolar coagulation could result in damage to the ovarian reserve. To avoid damage to healthy ovarian tissue, hemostasis using various topical hemostatic agents has been introduced to control post- cystectomy ovarian wound bleeding. Among these, FloSeal (Baxter Healthcare Corporation, Deer- field, IL, USA) is a hemostatic sealant composed of a gelatin-based matrix and thrombin solution. Aim: The aim of the study is to evaluate the impact of topical hemostatic sealants and bipolar coagulation during laparoscopic ovarian benign cyst resection on ovarian reserve by comparing the rates of decrease in anti- Mùˆllerian hormone (AMH). Methods: A randomized prospective data collection was made on women aged 18-45 years who planned to have laparoscopic ovarian cystectomy at one of two institutions (n = 80), Montpellier University Hospital and Nimes University Hospital, France. Patients were randomly divided into two groups treated with either a topical hemostatic sealant (Floseal) or bipolar coagulation for hemostasis. Preoperative, 3-month and 6-month postoperative AMH levels were checked and the rates of decrease of AMH were compared.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05037552
Study type Interventional
Source University Hospital, Montpellier
Contact Martha DURAES, MD
Phone +334 67 33 65 32
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date September 30, 2021
Completion date April 30, 2025

See also
  Status Clinical Trial Phase
Recruiting NCT03500744 - Erector Spinae Plane Block for Major Gynecologic and Urologic Surgery Phase 2/Phase 3
Recruiting NCT04300231 - Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy Phase 3
Recruiting NCT04118712 - Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age
Completed NCT02238886 - Radical Cystectomy, Nutrition and Convalescence N/A
Completed NCT04028934 - Study of the Quality of Life of Patients Treated by Heavy Surgery as Part of an Enhanced Recovery at Beau Soleil Clinic- QUALICHIR
Recruiting NCT00454038 - Study of Collagen Membrane in Guided Bone Regeneration Phase 1/Phase 2
Completed NCT02665156 - Time Efficiency of Intracorporeal Orthotopic Diversion With Robotic Staplers After Robot Assisted Radical Cystectomy N/A
Terminated NCT01245660 - A Phase 0 of Neoadjuvant Lapatinib in Infiltrative Bladder Carcinoma Before Cystectomy Phase 0
Recruiting NCT03280459 - Evaluation of Robot-assisted Intracorporeal Urinary Reconstruction N/A
Completed NCT00969514 - Robotic-Assisted Laparoscopic Cystectomy N/A
Completed NCT00577785 - Study to Obtain Full Thickness Bladder Tissue From Subjects Undergoing Cystectomy Surgery N/A