Comparisom of Liquid Nitrogen and Vitamin D3 in The Treatment of Cutaneous Warts

Cutaneous Warts Clinical Trial

Official title:

Comparison of Efficacy of Liquid Nitrogen Versus Vitamin D3 in The Treatment of Cutaneous Warts

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05739786
• Other study ID #: CMHAtd-ETH-17-DERM-22
• Status: Completed
• Phase: Phase 1
• Start date: May 11, 2022
• Est. completion date: November 11, 2022

Study information

• Verified date: February 2023
• Source: Combined Military Hospital Abbottabad
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A total of 60 female patients (30 patients in each group) with cutaneious warts diagnosed by a consultant dermatologist on physical examination were included in this study. In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) while patients in Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness in both groups was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: November 11, 2022
• Est. primary completion date: November 11, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patient of cutaneous warts presented in dermatology department.

Exclusion Criteria:

• Immunosuppressed patients
• chronic skin diseases like eczema or autoimmune disease
• diabetes mellitus
• cold sensitivity , skin allergies
• pregnancy, and lactation
• periungual warts

Related Conditions & MeSH terms

• Cutaneous Warts
• Warts

Intervention

Drug:
• liq nitrogen
In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) for 3 sessions at every 3 weeks interval. Effectiveness in was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.
• intralesional vitamin D3
Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Locations

Country	Name	City	State
Pakistan	Sara Ilyas	Abbottabad	Kpk

Sponsors (1)

Lead Sponsor	Collaborator
Combined Military Hospital Abbottabad

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effectiveness of liquid nitrogen and intralesional vitamin D3 in treatment of cutaneous warts	For 2nd Article: A total of 60 female patients (30 patients in each group) with cutaneous warts diagnosed by a consultant dermatologist on physical examination were included in this study.; In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) while patients in Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness in both groups was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.Total duration of therapy for each patient will be 9 weeks after "recurrence and remission"	9 weeks