Cutaneous Vasculitis Clinical Trial
Official title:
Retrospective Analysis of Frequency of Systemic Involvement in IgA-positive Cutaneous Immune Complex Vasculitis Versus IgA-negative Cutaneous Immune Complex Vasculitis
Cutaneous vasculitis due to vascular deposition of large circulating immune complexes is a
disease frequently seen by general practitioners and dermatologists. The clinical symptom is
palpable purpura with predilection for the lower legs.
In some cases vasculitis also affects systemic organs, such as the kidneys and the
intestine.
When the immune complexes contain immunoglobulin class A (IgA) and when there is systemic
involvement, the disease has been referred to as Henoch Schönlein purpura.
When there are no signs of systemic involvement, the disease has been referred to as
cutaneous leukocytoclastic angiitis.
The investigators hypothesize that palpable purpura with predilection for lower legs is a
pathognomonic clinical sign for immune complex vasculitis in both IgA vasculitis and
IgA-negative vasculitis, but that only the presence of IgA in immune complexes is likely to
be associated with systemic involvement and therefore warrants more extensive diagnostic
procedures Vice versa the investigators postulate that the presence of IgG or IgM without
IgA in immune complexes excludes systemic involvement The investigators also want to
investigate to which of the 2 groups patients with palpable purpura and negative
immunofluorescence should be assigned.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02967068 -
VCRC Tissue Repository
|