Skin Lesion Clinical Trial
Official title:
Photoprotective Effects of the RV 2457C Sunscreen Milk in Photoinduced Cutaneous Lupus Erythematosus
Lupus erythematosus (LE) is characterized by a large clinical spectrum, and sunligt is a
well established factor in the induction and exacerbation of this disease. In all subsets of
LE, skin lesions occur preferentially in sun-exposed areas.
Previous studies have demonstrated that the lesions in LE patients reproduced in controlled
experimental conditions. The initial reports suggested that the action spectrum for the LE
was in the UVB range (290 to 320 nm), but more recent studies have demonstrated that UVA
(320 to 400 nm) can contribute to the induction of LE skin lesions.
Antimalarial agents and topical steroids are the main treatments of chronic LE. The second
line therapies include retinoids, sulfones, immunosuppressor agents, systemic corticosteroid
and thalidomide. Moreover, patients are advised to avoid sun, to wear sunprotective clothing
and to apply sunscreen.
The aim of this study was to assess the efficacy of a sunscreen milk with high protection
factor against UV-B and UV-A, used exclusively, in the photoinduced LE.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention
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