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NCT00081341 Clinical Trial

Cognition, Steroids, and Imaging in Cushings Disease

Cushing Syndrome Clinical Trial

Official title:
Cognition, Steroids, and Imaging in Cushings Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00081341
Other study ID # 51337DK (completed)
Secondary ID
Status Completed
Phase N/A
First received April 8, 2004
Last updated February 12, 2010
Est. completion date December 2002

Study information
Verified date February 2010
Source National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

This study investigates the effects of the glucocorticoid hormone cortisol on brain structure and function. Patients with Cushing's disease are studied before and after treatment. Brain imaging and neuropsychologic tests are used to study changes in the hippocampus and thinking and learning functions as well as mood during the period of elevated cortisol. At several intervals after treatment, these are reexamined to study the degree of reversibility of the abnormalities. The contribution of cortisol as well as testosterone and estrogen to dysfunction and recovery is studied. Since elevated cortisol and dysregulation of its secretory system occurs in a significant proportion of the aged and in Alzheimers Disease and Major Depressive Disorder, these studies will help advance knowledge of the role of cortisol in these conditions.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date December 2002
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 9 Years and older
Eligibility Inclusion criteria:

- patients with suspected Cushing's syndrome with clinical findings suggestive of Cushing's syndrome and positive screening tests (urinary free cortisol and low dose overnight dexamethasone suppression test).

Exclusion criteria: none

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United States General Clinical Research Center, University of Michigan Health System Ann Arbor Michigan

Sponsors (1)
Lead Sponsor Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Country where clinical trial is conducted

United States, 

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