CTTN Protein in ESCC Clinical Trial
Lung cancer and esophageal cancer remain the leading causes of cancer death worldwide. The
main problem is lack of effective tool in early detection that accounts for the poor outcome
of cancer. Clinically, over 80% of patients with cancer were at late stage when they were
diagnosed. Therefore, it is important for us to find the biomarker that serve as the early
prediction of cancer.
The investigators have published that VEGFC over-expressed in non-small cell lung cancer.
VEGFC plays a critical role in regulating motility of tumor cells, promotes proliferation of
lymphatic endothelial cells and enhances migration and invasion. Investigator found that
VEGFC over-expressed in the serum of esophageal cancer patients. Therefore, it is worthwhile
to investigate the correlation between VEGFC, clinical lung cancer and esophageal cancer.
MicroRNAs (miRNAs) are conserved, endogenous, small, and noncoding RNA molecules of 21~23
nucleotides that function as post-transcriptional gene regulators. Recent studies indicated
that certain microRNAs reduced in cancer patients. Therefore it is important to investigate
whether specific microRNA changed in certain kinds of cancer patients.
| Status | Active, not recruiting |
| Enrollment | 250 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 50 Years to 80 Years |
| Eligibility |
Inclusion Criteria: - tumor size > 0.5 cm3 Exclusion Criteria: - tumor size < 0.5 cm3 |
Observational Model: Case-Only, Time Perspective: Cross-Sectional
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| China Medical University Hospital |