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Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia — ACACIA  

Cryptococcal Meningitis Clinical Trial

Official title:
Evaluation of CrAg Screening With Enhanced Antifungal Therapy for Asymptomatic CrAg+ Persons

Clinical Trial Summary

This will be a randomized controlled trial of asymptomatic (Cryptococcal Antigen test)CrAg positive persons in Uganda. Patients will be randomized to receive preemptive treatment with 1 dose of liposomal amphotericin (10mg/kg) in addition to standard of care fluconazole therapy. How the enhanced antifungal therapy prevents progression to meningitis in the first 24-weeks and overall survival in those who receive the intervention compared with participants receiving fluconazole per World Health Organisation (WHO) and national standard of care therapy will be evaluated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03945448
Study type Interventional
Source Makerere University
Contact DAVID MEYA, PhD
Phone +256 772 543 730
Email david.meya@gmail.com
Status Recruiting
Phase Phase 2/Phase 3
Start date June 20, 2019
Completion date April 2028
View Details
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