Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT06193226 |
Other study ID # |
RECO6U/11-2023 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
February 1, 2023 |
Est. completion date |
October 1, 2023 |
Study information
Verified date |
January 2024 |
Source |
October 6 University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The aim of this study is to evaluate the effectiveness of cryotherapy as a therapeutic option
for oral lesions.
Description:
Low-temperature applications were originally employed by the Egyptians to treat pain, and
subsequently during the Franco-Prussian War for severed limbs. Hippocrates advocated the
application of cold to lessen bruising, bleeding, and discomfort, while John Hunter wrote in
1777 that "the local tissue response to freezing includes local tissue necrosis, vascular
stasis, and excellent healing." Using a solution of salt and ice, James Arnott (1851) was the
first to describe and demonstrate this freezing technique for malignant breast tumors.
The term "cryotherapy" was used in 1908 to describe the use of extremely low temperatures to
cure skin lesions. Currently, cryotherapy involves cooling the body's surface without
destroying tissue, whereas in cryosurgery, sick tissues are frozen to death.
In the technique, several cryogens include: liquid nitroglycerine (-196 °C), Nitrous oxide
(0°C), Solid CO2 (-78o C), Chlorodifluoromethane (-41°C), Dimethyl ether (-24 °C) and propane
(-42 °C).
The intralesional technique, open method, or closed method can all be used to apply cryogens.
The best application approach for big superficial cutaneous lesions is an open spray
technique, in which the spray's nozzle is situated 1 cm away from the skin's surface, and the
lesion is destroyed using either a paintbrush technique or a spiral technique.