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Clinical Trial Summary

The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease.


Clinical Trial Description

The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease. This assay provides a means to measure Cl- secretion across the sinus epithelium in human subjects with chronic rhinosinusitis (CRS) and test the relationship between this data and endoscopic findings of inflammation. The technique is appropriate for investigating acquired CFTR dysfunction in sinus epithelium and examining the therapeutic potential of CFTR potentiators for CRS. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02997020
Study type Observational
Source University of Alabama at Birmingham
Contact
Status Active, not recruiting
Phase
Start date May 18, 2017
Completion date December 2022

See also
  Status Clinical Trial Phase
Completed NCT03379701 - Applications of Nanotechnology and Chemical Sensors for the Detection and Identification of Chronic Sinusitis Subtypes by Respiratory Samples N/A
Recruiting NCT04868695 - SUBJECTIVE AND OBJECTIVE OUTCOME OF ENDOSCOPIC SINUS SURGERY IN PATIENTS WITH CHRONIC RHINOSINUSITIS WITH NASAL POLYPS N/A