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Crohn's Ileocolitis clinical trials

View clinical trials related to Crohn's Ileocolitis.

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NCT ID: NCT05332639 Not yet recruiting - Crohn Disease Clinical Trials

Personalized Risk Estimation for Crohn's Disease (PRE-CD): Implementation and Feasibility

Start date: February 2025
Phase: N/A
Study type: Interventional

The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-CD) tool on behaviors and biomarkers associated with risk for Crohn's disease in unaffected first-degree relatives of patients with inflammatory bowel disease. We hypothesize that personalized risk disclosure via the PRE-CD educational tool is both feasible and successful in modifying behaviors associated with Crohn's disease risk and normalizing pre-clinical disease biomarkers when compared to standard Crohn's disease education. Broadly, completion of this project will also help elucidate the role of lifestyle and dietary factors in pre-clinical Crohn's disease development in high-risk individuals, and provide novel insight into potential strategies for disease prevention in this population.

NCT ID: NCT05246917 Recruiting - Crohn Disease Clinical Trials

Comparing Manual Versus Stapled Side to Side Ileocolic Anastomosis in Crohn's Disease

HAND2END
Start date: May 25, 2022
Phase: N/A
Study type: Interventional

RESEARCH QUESTION Are handsewn (end to end and Kono S side to side) anastomoses superior to side to side stapled anastomosis after ileocolic resection for Crohn's disease with respect to endoscopic recurrence, gastrointestinal function and costs. HYPOTHESIS Stapled side anastomosis advised in ECCO guidelines heal with ulcerations on the staple line causing systematic over scoring of endoscopic recurrence leading to unjustified restarting of expensive drugs reducing QOL and increasing costs. Side to side saccular configuration causes stasis affecting recurrence and dysfunction. DESIGN Randomised superiority study POPULATION Patients with Crohn requiring (re)resection of the (neo)terminal ileum INTERVENTION Kono S and end to end hand sewn anastomosis USUAL CARE Side to side stapled anastomosis OUTCOME Endoscopic recurrence (local and central reading) at 6 months SAMPLE 25% reduction in 2:1 ratio -> 126 + 63 = 189 patients KEYWORDS Crohn, ileocolic resection, recurrence

NCT ID: NCT04623476 Recruiting - Crohn Disease Clinical Trials

PAtophysiological, Nodal-based Approach for Crohn's Disease Excision

PANACEAPILOT
Start date: November 16, 2020
Phase: N/A
Study type: Interventional

Single centre prospective pilot study on surgery for Crohn's disease (CD). CD universally recurs after surgery and no technique so far has been proven to reduce recurrence. The investigators speculate that a different surgical technique, based on pathophysiology of the disease may prove successful in reducing rates of recurrence. Consecutive CD patients with a surgical indication for ileocolic disease will receive an extended procedure including a lymphadenectomy (Pathophysiologic excision for Crohn's disease). Primary outcome will be endoscopic recurrence rates at 6 and 12 months from surgery.

NCT ID: NCT04539665 Recruiting - Crohn Disease Clinical Trials

Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease.

Start date: September 27, 2019
Phase: N/A
Study type: Interventional

The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first ileocolic resection for Crohn's disease. Endoscopic recurrence will be monitored with the hypothesis that patients receiving extended mesenteric ileocolic resection will have reduced endoscopic recurrence at 6 months after resection.

NCT ID: NCT04266600 Recruiting - Crohn Disease Clinical Trials

Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease

Start date: September 27, 2019
Phase: N/A
Study type: Interventional

The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first ileocolic resection for Crohn's disease. Endoscopic recurrence will be monitored with the hypothesis that patients receiving extended mesenteric ileocolic resection will have reduced endoscopic recurrence at 6 months after resection. (limited mesenteric resection).

NCT ID: NCT04100005 Recruiting - Crohn Disease Clinical Trials

A Pilot Study to Explore the Role of Gut Flora in Crohn's Disease

Start date: March 2, 2020
Phase:
Study type: Observational [Patient Registry]

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Crohn's disease.

NCT ID: NCT02281916 Completed - Crohn's Ileocolitis Clinical Trials

Safety Study of P28GST Treatment in Crohn's Disease Patients

ACROHNEM
Start date: March 2014
Phase: Phase 2
Study type: Interventional

This multicenter phase 2 clinical trial is designed to assess safety of P28GST (protein 28 Kd glutathion S Transferrase), aiming to control inflammation in moderate Crohn's Disease (CD), before or after intestinal resection surgery. P28GST is a parasite enzyme molecule from Schistosoma with potent immunogenic and anti-oxidant properties. Based on experimental evidence of its anti-inflammatory properties, the investigators hypothesized that administration of P28GST could protect against recurrence after intestinal resection surgery in CD.