Crohn's Disease Clinical Trial
Official title:
Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission: Functional MRI Study
Crohn's disease goes along with an alteration of the quality of life, even in remission and
has a negative impact on stress management linked to the pain and the health. Conversely,
stress and psychological variables play a significant role in the pathogenesis of this
disease. These interrelations reflects the link between the brain and the digestive tract,
called brain-gut axis. The autonomic nervous system (ANS) is the neurological interface,
relaying in a bidirectional way, informations between the digestive tract and the central
nervous system (CNS).
Visceral information can thus modulate the functionnement of CNS's areas involved in pain
management but also in the management of emotional and cognitive behaviours. Yet, numerous
work demonstrate the existence of a dysfunction of the ANS during Crohn's disease, with a
dysautonomia of the sympatho-vagal balance.
Human brain respond by advance before and during the application of a painful stimulus that
enable the organism to regulate its nociceptive system in order to handle the aversive
stimulus incoming, via the activation of brin areas managing the pain, or the raise of pain
awareness.
The uncertain and not predictable nature of a painful crisis and/or an inflammatory relapse
in a chronic disease like Crohn's disease can be the origin of an anticipating apprehension
and anxiety, that could influence visceral perception (increasing it). Nevertheless, only
few studies exists about the differential role of certain or uncertain anticipation of the
pain, despite the fact that they are associated to different emotional, cognitive and
behavioral responses, and the effect of anticipation on painful visceral perception, have
not yet been studied for parents in remission of Crohn's disease.
The main goal is to search during certain and uncertain visceral anticipation, induced by
distension of an intra-rectal balloon for persons suffering from Crohn's disease in
remission, compared to control subjects, with an MRI functional study
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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