Crohn's Disease Clinical Trial
Official title:
Controlled, Randomized, Double Blind Study, Comparing Curcumin to Thiopurines in the Prevention of Post-op Recurrence in Crohn Disease
Curcumin, the active ingredient of turmeric, has been used for long term in the treatment of
inflammatory conditions. Inhibition of NF-κB is postulated as the main mechanism responsible
for the anti-inflammatory effect of curcumin
Aim : to study the effect of curcumin, 3g per day, as compared to placebo, combined with
thiopurines in the prevention of Crohn's disease post-operative recurrence.
122 subjects, operated on for Crohn disease, will be included in the study. After ileo-colonic resection, subjects will be randomized into two arms; they will be given either placebo or curcumin 3g/d per os plus thiopurines during 6 months in a double-blind manner. Rutggerts endoscopic score at 6 months will be the main judgment criteria. ;
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