Manipulating the Microbiome in IBD by Antibiotics and FMT — FMT  

Crohn's Colitis Clinical Trial

Official title: Manipulating the Microbiome in IBD by Antibiotics and Fecal Microbiota Transplantation (FMT): a Randomized Controlled Trial

Status Completed

Clinical Trial Summary

the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut microbiome. The results of previous studies on the effectiveness of antibiotics and fecal macrobiota transplantation (FMT) are contradicting.

Aims: to evaluate the effectiveness of wide-spectrum antibiotic regimens in acute severe colitis in an addition to standard corticosteroid therapy (UC and isolated "UC-like" Crohn's colitis). The secondary aim is to assess the outcome of FMT in those not responding to five days of therapy (in either arm). As an exploratory aim, any IBD patient with a resistant disease to at least two immunosuppressive medications, may be treated with either interventions.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Colitis
• Colitis, Ulcerative
• Crohn's Colitis
• Exacerbation of Ulcerative Colitis
• Ulcer
• Ulcerative Colitis, Active Severe

• NCT number: NCT02033408
• Study type: Interventional
• Source: Shaare Zedek Medical Center
• Status: Completed
• Phase: N/A
• Start date: January 2014
• Completion date: January 2021