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Clinical Trial Summary

Crohn's disease is a multifactorial complex disease resulting in a between microbiota and immune system. Indeed, GWAS (Genome-Wide Association Studies) association study pinpointed polymorphisms as genes susceptibility on more than 200 loci. Among them genes coding for proteins involved in autophagy machinery (i.e: ATG16L1, IRGM et NDP52). Autophagy is a ubiquitous intracellular mechanism mandatory for protein and microorganism recycling. So far, the role of autophagy in gut inflammation and intestinal homeostasis in Crohn's disease patients is partially understand. Then, investigators plan to evaluate, on native cells, the autophagic flux in pediatric patients suffering of a Crohn's disease compare to controls.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05842564
Study type Interventional
Source Hospices Civils de Lyon
Contact Rémi DUCLAUX-LORAS, MD, PhD
Phone 0472357050
Email remi.duclaux-loras@chu-lyon.fr
Status Not yet recruiting
Phase N/A
Start date June 2023
Completion date September 2025

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