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N-3 Polyunsaturated Fatty Acids Prevent Postoperative Recurrence of Crohn's Disease

Crohn Disease Clinical Trial

Official title:
N-3 Polyunsaturated Fatty Acids Prevent Postoperative Recurrence of Crohn's Diseaseļ¼ša Prospective Randomized Controlled Trial

Clinical Trial Summary

Crohn's disease (CD) is a chronic recurrent intestinal inflammation involving the whole digestive tract, with high disability rate, high surgical rate and high recurrent rate postoperatively. Preventing postoperative recurrence in CD patients is an important clinical problem needed urgent intervention. Azathioprine (AZA) and infliximab (IFX) effectively prevent postoperative recurrence in CD patients, but the postoperative recurrence rate is still as high as 41%. Oral supplement of n-3 polyunsaturated fatty acids (n-3 PUFA) owns the advantages of high compliance and low economic cost. We aim to evaluate the effect of routine treatment (AZA/IFX) combined with long-term dietary n-3PUFA on the prevention and treatment of postoperative recurrence of CD, which help optimize the treatment strategy for the prevention of postoperative recurrence.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04761952
Study type Interventional
Source Sixth Affiliated Hospital, Sun Yat-sen University
Contact
Status Not yet recruiting
Phase N/A
Start date February 13, 2021
Completion date December 31, 2023
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