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The Therapy Effect of Azathioprine Initial or 14 Weeks After Combined With Infliximab on CD

Crohn Disease Clinical Trial

Official title:
The Therapy Effect of Azathioprine Initial or 14 Weeks After Combined With Infliximab on Crohn Diseaseļ¼ša Randomized, Open Label, Single-center Cohort Study

Clinical Trial Summary

This study aim to identify the therapeutic effect of azathioprine during infliximab(IFX) treatment in Crohn`s disease (CD).Half of patients will receive azathioprine and infliximab combination therapy at the same time. The other half patients will be given infliximab therapy first and then receive azathioprine 14 weeks later.

Clinical Trial Description

Anti-tumor necrosis factor agents were widely used for many years and were proved to be most reliable drugs in Crohn`s disease (CD). About one-third of the patients would develop a secondary lost of response after initiating IFX therapy in one year follow-up. Immunosuppressor was thought to be a useful agent to reduce loss of response rate of infliximab.But It remain unclear when should us add immunosuppressor during infliximab therapy.This study aim to find the most valuable timepoint to initiate combination therapy to maximize therapeutic effect and minimize the adverse effect. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03393247
Study type Interventional
Source Sixth Affiliated Hospital, Sun Yat-sen University
Contact Jian Tang, master
Phone 8613751879964
Email tangjiansys@163.com
Status Recruiting
Phase N/A
Start date June 1, 2017
Completion date July 1, 2019
View Details
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