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NCT03272152 Clinical Trial

Comprehensive DNA Methylation Profiling in Crohn's Disease

Crohn Disease Clinical Trial

Official title:
Comprehensive DNA Methylation Profiling of Inflammatory and Non-Inflammatory Mucosa in Crohn's Disease

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03272152
Other study ID # 20170808
Secondary ID
Status Recruiting
Phase N/A
First received August 31, 2017
Last updated August 31, 2017
Start date January 1, 2017
Est. completion date September 30, 2017

Study information
Verified date August 2017
Source Jinling Hospital, China
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's disease was performed. Genome-wide DNA methylation was determined using the Illumina HumanMethylation 850k BeadChip.

Recruitment information / eligibility
Status Recruiting
Enrollment 14
Est. completion date September 30, 2017
Est. primary completion date September 30, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- Active Crohn's disease(CDAI score= 150)

Exclusion Criteria:

- No ileal lesions

- Under treatment of immunomodulators, biologic agents or steroids

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• Genome-wide DNA methylation
Genome-wide DNA methylation was determined using the Infinium Human Methylation 850K BeadChip.

Locations
Country Name City State
China Jinling Hospital Nanjing Jiangsu

Sponsors (1)
Lead Sponsor Collaborator
Jinling Hospital, China

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Intestinal inflammation under colonoscopy Intestinal ulcer or enteritisis observed under colonoscopy Jan 2017 to Sep 2017
Secondary CDAI Crohns Disease Activity Index is measured. Jan 2017 to Sep 2017
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