Diet as Essential Therapy (DIET) for Inflammatory Bowel Disease

Crohn Disease Clinical Trial

Official title: Randomized Trial of Diet for Crohn's Disease and Impact on Disease Activity and the Microbiome

Status Recruiting

Clinical Trial Summary

Recent data suggest that diet in inflammatory bowel disease (IBD) may lead to both symptom control and disease remission. Historically certain diets have been recommended for patients with Crohn's disease during exacerbations despite lack of data supporting efficacy. The investigators propose to evaluate two such diets by randomizing 32 subjects with mildly to moderately active Crohn's disease to one of two diets that differ in the amount and type of carbohydrates and fiber. Subjects will remain on the diet for 8 weeks and will be evaluated for changes from baseline in inflammatory biomarkers, symptomatic disease activity, and the microbiome.

Clinical Trial Description

Subjects will be randomized in a 1:1 ratio to receive one of two diets that are thought to be beneficial for Crohn's disease for a period of 8 weeks.

Initial evaluation will include a clinic visit with physical exam, medication review, supplemental documentation, and labs. Patients will be asked about their food allergies and intolerances against a master list of all ingredients used in both diets. Patients will then be provided with instructions on how to record their baseline dietary intake for two weeks prior to the intervention diet.

At day 0 patients will begin their study diet. All study meals will be provided to the subject and an approved snack list for the randomized diet will be provided in a sealed envelope with their first week of meals.

At the conclusion of intervention patients will be asked to resume their previous diet for 4 weeks and record their dietary intake. Stool and blood will be collected at baseline and at 4, 8, and 12 weeks. At the conclusion of the study patients will be told which diet they were on and will be provided with dietary consultation by a registered dietitian.

Subjects who withdraw from the study before the 4 week assessment will be asked to provide a final stool sample at the time of withdrawal. If more than 2 subjects drop out prior to week 4, subject replacement will occur. ;

Related Conditions & MeSH terms

• Crohn Disease
• Inflammatory Bowel Diseases

• NCT number: NCT03012542
• Study type: Interventional
• Source: University of Washington
• Contact: Timothy L Zisman, MD, MPH
• Phone: 206-543-3220
• Email: tzisman@medicine.washington.edu
• Status: Recruiting
• Phase: N/A
• Start date: January 2017
• Completion date: December 2019