Crohn Disease Clinical Trial
Official title:
Genomic/Epigenomic Biomarkers of Deregulation of Immune System in Inflammatory Bowel Diseases: Prediction of Post-operating Natural History of Crohn's Disease
The purpose is to search for enterocyte-specific or non-specific molecular signature of
post-operating recurrence of Crohn's disease in transcriptome (measurement of gene
expression through number of mRNA copies transcribed for each gene) and in methylome.
Secondary objectives are to compare expression and methylation profiles according to:
- treatment response
- morphological (endoscopic and/or radiological) and clinical post-operating recurrence.
This aim of this study is to search for new biomarkers predictive of post-operating
recurrence.
At present, there are no biomarkers predictive for post-operating recurrence and
administration of a post-operating medical treatment to prevent recurrence is based on
biological, endoscopic and imagery data.
Predictive biomarkers could allow the identification of patients with high risk of
post-operating recurrence and administration of a systematic prophylactic post-operating
treatment and at the same time avoiding the prescription of this treatment to patients with
low risk of post-operating recurrence.
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Observational Model: Cohort, Time Perspective: Prospective
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