Metabolic and Nutritional Characteristics of Long-stayer ICU Patients

Critically Ill Clinical Trial

— Nutri-ICU-LS  

Official title:

Long-stayer Critically Ill Patients: is the Metabolic and Nutritional Therapy in the ICU Creating the Problem?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03938961
• Other study ID #: CER2018-02018
• Status: Completed
• Start date: February 1, 2017
• Est. completion date: April 13, 2020

Study information

• Verified date: April 2020
• Source: Centre Hospitalier Universitaire Vaudois
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The intensive care (ICU) patient population has increasing number of very long ICU stays. Long-stayers are usually defined as requiring more than 1 week of mechanical ventilation and of ICU therapy: little is know about their metabolic characteristics and their relation to outcome. The study aims at describing the demographic, nutritional and metabolic aspects of their stay.

Analysis of 200-250 consecutive patients admitted to the ICU long-stayer program.

Description:

Data extracted from the computerized ICU system (PDMS): age, Simplified acute physiology score (SAPSII), weight, BMI, Nutrition Risk Score (NRS-2002), daily energy, protein, and glucose intakes, Energy balance, blood glucose (dysglycemia and Glu variability) and lactate, 24hr-insulin (Goal Glu 6-8 mmol/l).

Outcome variables: length of stay (LICU), muscle strength (MRC), vital status at 90 days.

Patients will be followed in detail until ICU discharge and for vital status until day 90 after admission Data will be presented as mean or median, univariate and multivariate analysis will be performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 205
• Est. completion date: April 13, 2020
• Est. primary completion date: April 13, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• ICU length of stay > 7 days and enrollment to the long-stayer ICU program

Exclusion Criteria:

• Major burns

• Brain injury

• Severe neurological condition as primary disease

Related Conditions & MeSH terms

• Critical Illness
• Critically Ill

Locations

Country	Name	City	State
Switzerland	Adult ICU and Burns, University of Lausanne Hospital	Lausanne	Vaud

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire Vaudois

Country where clinical trial is conducted

Switzerland, 

References & Publications (2)

Loss SH, Nunes DSL, Franzosi OS, Salazar GS, Teixeira C, Vieira SRR. Chronic critical illness: are we saving patients or creating victims? Rev Bras Ter Intensiva. 2017 Jan-Mar;29(1):87-95. doi: 10.5935/0103-507X.20170013. Review. Portuguese, English. — View Citation

Viana MV, Pantet O, Bagnoud G, Martinez A, Favre E, Charrière M, Favre D, Eckert P, Berger MM. Metabolic and Nutritional Characteristics of Long-Stay Critically Ill Patients. J Clin Med. 2019 Jul 7;8(7). pii: E985. doi: 10.3390/jcm8070985. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Decubitus ulcer	Appearance of decubitus ulcer during ICU stay	up to 90 days
Primary	Vital Status	Alive or dead at 90 days after ICU admission	up to 90 days
Secondary	Force	Muscle strength measured by Medical research Council (MRC) score	up to 90 days