The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

Critically Ill Clinical Trial

Official title:

The Correlation Between BNP and Global End Diastolic Volume

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01344265
• Other study ID #: zh_zhang1984
• Status: Completed
• Phase: N/A
• First received: April 27, 2011
• Last updated: April 1, 2013
• Start date: June 2010
• Est. completion date: October 2011

Study information

• Verified date: September 2012
• Source: Jinhua Central Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: SFDA
• Study type: Observational

Clinical Trial Summary

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: October 2011
• Est. primary completion date: October 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria:

• patients with renal dysfunction

• those older than 80 years

• pregnant women

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Critical Illness
• Critically Ill

Locations

Country	Name	City	State
China	Jinhua central hospital	Jinhua	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Jinhua Central Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	global end diastolic volume	this is measured by transpulmonary thermodilution technique	within 12 h after measurement of BNP	Yes