Clinical Trials Logo

Clinical Trial Summary

Advances in critical care medicine have dramatically improved the survival of critically ill patients requiring prolonged mechanical ventilation. However, there are no systematic follow-up, rehabilitation, or psychoeducational interventions for these vulnerable patients or their family caregivers who contribute to survivor recovery and rehabilitation. Major barriers to developing these programs for survivors of prolonged mechanical ventilation and their caregivers include the following:

1. There is inadequate information about the determinants of long-term functional outcomes for a diverse group of survivors of prolonged mechanical ventilation.

2. There is inadequate information about the needs of survivors of prolonged mechanical ventilation and their family caregivers across the trajectory of illness (i.e., from the ICU to the community).

3. There is a poor understanding of the development of ICU-acquired muscle injury.

Towards RECOVER is the very first study to identify survivors of prolonged mechanical ventilation who are at-risk for poor functional outcomes, to identify elements of the care-giving situation that put caregivers at risk for poor quality of life and mental health, to catalogue the rehabilitative needs of patients and family caregivers across the illness trajectory, and to evaluate the mechanism of critical illness associated muscle injury.

The RECOVER Program consists of Four Phases:

- Phase I: Towards RECOVER

- Phase II: RECOVER development and pilot testing

- Phase III: RECOVER randomized controlled trial

- Phase IV: Long-term implementation of RECOVER


Clinical Trial Description

n/a


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT00896220
Study type Observational
Source University Health Network, Toronto
Contact Andrea Matte, RRT
Phone 416-340-3057
Email andrea.matte@uhn.on.ca
Status Recruiting
Phase N/A
Start date April 2006
Completion date October 2012

See also
  Status Clinical Trial Phase
Recruiting NCT05539521 - Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation Phase 2
Recruiting NCT04776486 - Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance N/A
Completed NCT05766319 - The ICU-recover Box, Using Smart Technology for Monitoring Health Status After ICU Admission N/A
Recruiting NCT03231540 - The PREServation of MUScle Function in Critically Ill Patients (PRESMUS) N/A
Completed NCT02286869 - Cardioventilatory Coupling in Critically Ill Patients N/A
Completed NCT01434823 - 24 Hour Intensivist Coverage in the Medical Intensive Care Unit N/A
Active, not recruiting NCT01142570 - Effect of Enteral Nutrition Enriched in Protein and Based on Indirect Calorimetry Measurement in Chronically Critically Ill Patients N/A
Completed NCT01167595 - Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients N/A
Completed NCT01293708 - Realities, Expectations and Attitudes to Life Support Technologies in Intensive Care for Octogenarians:
Not yet recruiting NCT00916591 - Prokinetic Drugs and Enteral Nutrition N/A
Recruiting NCT00654797 - Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2 Phase 2
Withdrawn NCT00178321 - Improving Sleep in the Pediatric Intensive Care Unit N/A
Completed NCT01168128 - PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study N/A
Completed NCT02447692 - Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study N/A
Recruiting NCT04582760 - Early Mobilization in Ventilated sEpsis & Acute Respiratory Failure Study N/A
Not yet recruiting NCT05961631 - Bio-electrical Impedance Analysis Derived Parameters for Evaluating Fluid Accumulation
Completed NCT03276650 - Admission of Adult-onset Still Disease Patients in the ICU
Completed NCT03922113 - Muscle Function After Intensive Care
Recruiting NCT05055830 - Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
Recruiting NCT06027008 - Mechanical Insufflation-Exsufflation (Cough Assist) in Critically Ill Adults N/A