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NCT00205309 Clinical Trial

Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

Critically Ill Clinical Trial

Official title:
Respiratory Tract IgA Levels in Critically Ill Intubated Patients

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00205309
Other study ID # 2002-562
Secondary ID
Status Completed
Phase N/A
First received September 13, 2005
Last updated October 16, 2012
Start date January 2003
Est. completion date June 2011

Study information
Verified date October 2012
Source University of Wisconsin, Madison
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.

Recruitment information / eligibility
Status Completed
Enrollment 13
Est. completion date June 2011
Est. primary completion date June 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Subjects must be intubated, intensive care patients.

Exclusion Criteria:

- No severe pulmonary contusions or evidence of airway bleeding

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United States University of Wisconsin Hospital and Clinics Madison Wisconsin

Sponsors (1)
Lead Sponsor Collaborator
University of Wisconsin, Madison

Country where clinical trial is conducted

United States, 

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