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Impact of Capillary Leak and Hypoalbuminemia on PK/PD of Anidulafungin and Caspofungin in Critically Ill Patients

Critically Ill Patients Clinical Trial

Official title:
Impact of Capillary Leak and Hypoalbuminemia on PK/PD of Anidulafungin and Caspofungin in Critically Ill Patients

Clinical Trial Summary

This prospective study will explore the pharmacokinetic exposure and pharmacodynamics of the echinocandins (caspofungin or anidulafungin) in critically ill patients.

Clinical Trial Description

This non-randomized, monocenter pharmacokinetic study will be carried out in critically ill patients receiving multiple dose treatment with echinocandins (caspofungin or anidulafungin).

The pharmacokinetics and pharmacodynamics of the echinocandins in plasma and BAL will be determined. Especially, the relative contributions of two pathophysiological alterations (capillary leak and hypoalbuminemia) encountered in critically ill patients, will be explored.

Also other correlating covariates will be identified to provide a rationale for optimal dosing strategy in critically ill patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04045366
Study type Observational
Source Universitaire Ziekenhuizen Leuven
Contact Isabel Spriet, PharmD, PhD
Phone +32 16 34 30 80
Email isabel.spriet@uzleuven.be
Status Recruiting
Phase
Start date September 21, 2012
Completion date December 31, 2020
View Details
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