Pharmacokinetics Clinical Trial
Official title:
Pharmacokinetics of Liposomal Amphotericin B in Critically Ill vs. Non-critically Ill Hematological Patients: Exploration of Covariates
This prospective study will compare the pharmacokinetic exposure to liposomal amphotericin B between critically ill patients and non-critically ill (hematology) patients in an early and late exposure day.
This phase IV, open label, non-randomized, monocenter pharmacokinetic study will be carried
out in critically ill and non-critically ill (hematology) patients receiving multiple dose
treatment with L-AmB.
The pharmacokinetic exposure to liposomal amphotericin B in plasma, urine, BAL and ascitic
fluid will be compared between the two population groups in an early and late exposure day.
Correlating covariates will be identified to provide a rationale for optimal dosing strategy
in critically ill patients.
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