Gastric pH in Critically Ill Patients

Status Completed

Clinical Trial Summary

H2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. Various studies demonstrated superiority of proton pump inhibitors over H2-receptor antagonists in increasing gastric pH and in healing gastric acid-dependent diseases. It is unknown, whether proton pump inhibitors are more effective in increasing gastric pH than H2-receptor antagonists in critically ill patients requiring stress ulcer prophylaxis.

Clinical Trial Description

Gastric pH is measured continuously for 72 hours with a pipolar microelectrode placed between 7 and 15cm below the lower esophageal sphincter. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Critical Illness
Critically Ill Patients
Indication for Stress Ulcer Prophylaxis

Clinical Trial Details

NCT number	NCT00590928
Study type	Interventional
Source	Medical University of Vienna
Contact
Status	Completed
Phase	Phase 4
Start date	July 2004
Completion date	June 2006

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04045366` - Impact of Capillary Leak and Hypoalbuminemia on PK/PD of Anidulafungin and Caspofungin in Critically Ill Patients
Completed	`NCT01411553` - ECG Leadwires: Disposable Versus Cleaned, Reusable	N/A
Completed	`NCT00288743` - Adherence, Efficacy and Safety of an Insulin Protocol in the Critically Ill: A Prospective Observational Study	Phase 2
Recruiting	`NCT03529617` - Pharmacokinetics of Liposomal Amphotericin B in Critically Ill vs. Non-critically Ill Hematological Patients: Exploration of Covariates
Not yet recruiting	`NCT05564975` - Construction and Application of Pressure Injury Risk Prediction Model for Critically Ill Patients
Recruiting	`NCT06234787` - Continuous Subcutaneous Glucose Monitoring in Critical Patients
Completed	`NCT02198950` - Combined Determination of sTREM-1, PCT and CD64 in Diagnosing Sepsis
Recruiting	`NCT01317381` - ICG- Livertest Versus New Biomarkers as Prognostic Markers in Critically Ill ICG- Livertest Versus New Biomarkers as Prognostic Markers in Critically Ill	Phase 4
Completed	`NCT00470821` - Oral Melatonin in Critically Ill High-risk Patients	Phase 4
Completed	`NCT00460252` - Tight Glycemic Control by eMPC Algorithm in Medical ICU Patients.	N/A
Recruiting	`NCT06049979` - Correlation Between Intestinal Blood Flow and Intestinal Dysfunction in Critically Ill Patients
Active, not recruiting	`NCT04793568` - Human Recombinant Interferon Gamma-1b for the Prevention of Hospital-acquired Pneumonia in Critically Ill Patients: a Double-blind, International, Phase 2, Randomized, Placebo-controlled Trial - the PREV-HAP Study	Phase 2
Recruiting	`NCT05458687` - Traditional Chinese Medicine for Complications in Critically Ill Patients	N/A
Completed	`NCT01963013` - Non-returning Catheter Valve for Reducing CAUTI	N/A
Completed	`NCT01794468` - A New Monitor to Measure Dermal Blood Flow in Critically Ill Patients: a Preliminary Study	N/A
Completed	`NCT03469882` - High Protein Intake and Early Exercise in Adult Intensive Care Patients	N/A
Recruiting	`NCT04962204` - Virtual Visitation in Intensive Care Unit Study	N/A
Completed	`NCT03205592` - Ultrasound Assessment of Residual Gastric Content in Critically Ill Patients
Recruiting	`NCT01995565` - Regional Cerebral Hemodynamics Related to Global Hemodynamics	N/A
Completed	`NCT00143494` - The Estimation of Abdominal Pressure by the Bladder and Gastric Pressure	N/A