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Critically Ill Children clinical trials

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NCT ID: NCT06411873 Not yet recruiting - Enteral Nutrition Clinical Trials

The Effect of High Protein Enteral Nutrition on Critically Ill Postoperative Children

Start date: May 30, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is o determine the feasibility and efficacy of high enteral protein in critically ill postoperative children. It will also learn about the safety of high enteral protein for critically ill postoperative children. The main questions it aims to answer are: Does high enteral protein improve nitrogen balance in critically ill postoperative children? Does high enteral protein reduce levels of Intestinal Fatty Acid Binding Protein (I-FABP) in critically ill postoperative children? Researchers will compare high enteral protein to a standard enteral protein to see if high enteral protein works to improve nitrogen balance and reduces levels of Intestinal Fatty Acid Binding Protein (I-FABP) in critically ill postoperative children. Participants will: Take high enteral protein or standard enteral protein for 72 hours The nitrogen balance and I-FABP levels will be assessed both before and after enteral feeding. Monitoring and reporting of adverse events and serious adverse events will be conducted in accordance with good clinical practice guidelines.

NCT ID: NCT05179564 Completed - Acute Kidney Injury Clinical Trials

Renal Function Assessment in Critically Ill Children

IOHEXOL
Start date: May 20, 2018
Phase: N/A
Study type: Interventional

Identification of renal dysfunction in critically ill children is often delayed due to lack of accurate methods for evaluation of glomerular filtration rate (GFR). The investigators compared GFR measurement by the gold standard technique iohexol plasma clearance with estimated GFR (eGFR) based on selected established formulas incorporating the renal biomarkers creatinine, cystatin C and betatrace protein.

NCT ID: NCT03946345 Recruiting - Acute Kidney Injury Clinical Trials

Iohexol for Measuring Renal Function

HERO
Start date: May 1, 2019
Phase:
Study type: Observational

Approximately 25-35% of all children admitted to the paediatric intensive care unit (PICU) or neonatal intensive care unit (NICU) will develop Acute Kidney Injury (AKI) during the first seven days after admission. AKI is associated with a worse outcome, including an increased risk of mortality compared to patients without AKI. However, this AKI prevalence estimation is based on serum creatinine based glomerular filtration rate (eGFR), which is known to be inaccurate. The investigators postulate that measured GFR (mGFR) based on iohexol clearance in critically ill children will detect a higher prevalence of children with AKI than currently used methods based on endogenous markers. This study will additionally provide mechanistic knowledge on the relative contribution of GFR and renal transport to renal function in critically ill children.

NCT ID: NCT03391310 Completed - Pressure Ulcer Clinical Trials

Use of Honey for Pressure Ulcers in Critically Ill Children

Start date: September 2, 2017
Phase: N/A
Study type: Interventional

The enrolled children would be randomized to one of the groups 'study group' or 'Honey dressing group' or 'Group I' (honey dressing containing Active Leptospermum Honey also known as Manuka honey would be used), changed every alternate day for a maximum period of upto 8 weeks (in cases of stage IV ulcers) or till healthy granulation tissue appears, whichever is earlier and 'control group' or 'Standard treatment group ' or 'Group 2' (paraffin gauze is applied after application of povidone iodine). Randomization will be performed as per protocol. Primary outcome will be reduction in time to healing of any stage of pressure ulcer and secondary outcomes will be treatment failure and new onset infection of ulcer.

NCT ID: NCT03017664 Completed - Clinical trials for Critically Ill Children

Improvement Project To Optimizing Nutrition With Higher Protein and Calorie Pediatric Tube Feeding

Start date: January 15, 2018
Phase:
Study type: Observational

This quality improvement project will include a practice change based on national guidelines for the nutritional management of PICU patients.

NCT ID: NCT01260831 Completed - Clinical trials for Critically Ill Children

Evaluating Processes of Care & the Outcomes of Children in Hospital (EPOCH)

EPOCH
Start date: January 2011
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the impact of Bedside Paediatric Early Warning System (Bedside-PEWS) on early identification of children at risk for near and actual cardiopulmonary arrest, hospital mortality, processes of care and PICU resource utilization.