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Azithromycin for Critical Asthma - Pediatrics — CR-AZI Kids  

Critical Illness Clinical Trial

Official title:
Azithromycin as Immunomodulation Among Children Hospitalized for Critical Asthma: A Prospective, Open-Label, Non-Randomized, Interventional Study With Parallel Biospecimen Banking

Clinical Trial Summary

The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.

Clinical Trial Description

Azithromycin (AZI), a macrolide antibiotic, has been applied for adult and pediatric respiratory pathology to alter immune system response.1 For pediatric critical asthma (CA), a term used to describe a critically ill child hospitalized with an asthma exacerbation requiring an intensive care unit (PICU) hospitalization, the investigator's prior research has revealed 1 in 10 will receive AZI.2 Yet, the application of AZI in this setting is poorly studied nor is clear if, and to what degree AZI alters the immune response in conjunction with systemic corticosteroids traditionally applied in CA. In this proposal, the investigators aim to characterize a respiratory epithelial inflammatory biomarker, periostin, among children with CA with and without exposure to AZI. The investigators hypothesize children receiving AZI will have lower periostin levels. As a secondary analysis, the investigators will describe the rates of adverse events related to AZI (previously not done) and explore differences in clinical and physiologic CA efficacy markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06223828
Study type Interventional
Source Johns Hopkins All Children's Hospital
Contact Anthony A Sochet, MD
Phone 727-487-3711
Email Sochet@jhmi.edu
Status Recruiting
Phase Phase 2/Phase 3
Start date April 2, 2024
Completion date June 30, 2025
View Details
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