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Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study

Critical Illness Clinical Trial

Official title:
Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study

Clinical Trial Summary

This clinical trial aims to study intrarenal venous flow patterns change during fluid removal treatment in critically ill patients

Clinical Trial Description

Background: In patients with heart failure, intrarenal venous flow patterns could change depending on the level of congestion and was strongly correlated with death from cardiovascular disease and unplanned hospitalization. However, the findings may differ in patients with sepsis in the intensive care unit. In this case, Intrarenal venous flow patterns were not associated with Central Venous Pressure but were associated with Acute Kidney Injury and death. This suggests that intrarenal venous flow patterns may serve as an indicator of renal congestion and could be a feasible bedside tool to predict various clinical implications. Objective: We aimed to study intrarenal venous flow patterns change during fluid removal treatment in critically ill patients. Methods: - After enrollment, patients will undergo baseline Doppler ultrasonography to evaluate intrarenal venous flow patterns before the initiation of fluid removal through diuretic therapy or renal replacement therapy. - After patients received fluid removal therapy, they will receive continuous ultrasonography monitoring within 24, 48, and 72 hours, along with data collection. Researchers will collect data about - intrarenal venous flow patterns change, Venous Excess Ultrasound (VExUS) score change during fluid removal treatment - establish a correlation between alterations in intrarenal flow patterns and VExUS score, as well as other clinical data (Central venous pressure, Cumulative fluid balance) and clinical implications (Renal replacement therapy free day, Ventilator free day, length of Intensive care unit stay). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06216119
Study type Observational
Source Mahidol University
Contact Ranistha Ratanarat, MD
Phone +66896685287
Email ranittha@gmail.com
Status Recruiting
Phase
Start date December 19, 2023
Completion date February 28, 2025
View Details
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