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Intravenous Versus Subcutaneous Administration of Low Molecular Weight Heparin for Thromboprophylaxis in Critically Ill Patients

Critical Illness Clinical Trial

Official title:
Intravenous Versus Subcutaneous Administration of Low Molecular Weight Heparin for Thromboprophylaxis in Critically Ill Patients: a Randomized Controlled Trial

Clinical Trial Summary

Objective: To compare the pharmacokinetic profiles of intravenous versus subcutaneous route of administration of LMWH for thromboprophylaxis in critically ill patients

Clinical Trial Description

The study is a prospective, monocentric, randomized trial. Patients are randomized to the IV route of administration over a 4-hours infusion of nadroparin 3800 IU or to the SC route of administration. Randomization is stratified according to the need for vasopressor or not. Anti-Xa activity is measured at baseline, and at 1, 2, 4, 6, 8, 12 and 24 hours after the administration was started. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04982055
Study type Interventional
Source Clinique Saint Pierre Ottignies
Contact
Status Completed
Phase Phase 4
Start date April 8, 2015
Completion date December 31, 2020
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