Prognostic Significance of Red Blood Cell

Critical Illness Clinical Trial

Official title:

Prognostic Significance of Red Blood Cell Distribution Width (RDW) in Critically Ill Pediatric Patients at Sohag University Hospital

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04763239
• Other study ID #: Soh-Med-21-02-14
• Status: Completed
• Start date: March 1, 2021
• Est. completion date: August 1, 2022

Study information

• Verified date: August 2022
• Source: Sohag University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Red blood cell (RBC) distribution width (RDW), calculated by dividing the standard deviation of RBC volume by the mean corpuscular volume and multiplied by 100, is routinely reported as part of the complete blood count (CBC) using automated flow cytometry. RDW has been traditionally used as additional information in the differential diagnosis of the cause of anemia.

RDW has been recently reported as a strong prognostic factor in several diseases of various organ systems, including the cardiovascular, respiratory, renal, neurologic, and gastrointestinal systems.It also showed significant associations with ventilator-free days, postoperative outcome, intensive care unit (ICU) discharge outcome, out-of-hospital outcome, and all-cause mortality in critically ill patients. However, most studies were conducted in adult patients. Only a few studies have investigated RDW in children, especially in the critically ill pediatric population.

Description:

The aim of this study is to know the prognostic significance of red blood cell distribution width ( RDW ) in critically ill pediatric patients as regard ; the duration of hospital & PICU admission ,the use of inotropic drugs and or mechanical ventilation (MV) and the outcome of the case .

Recruitment information / eligibility

• Status: Completed
• Enrollment: 111
• Est. completion date: August 1, 2022
• Est. primary completion date: June 1, 2022
• Gender: All
• Age group: 1 Month to 12 Years

Eligibility

Inclusion Criteria:

• All critically ill pediatric patients, 1 month to 12 years age, admitted to Pediatric intermediate & Intensive Care Unit ( PICU ) in Sohag University Hospital.

Exclusion Criteria:

• - patients who received blood transfusion prior to admission in PICU

• patients with incomplete data for pediatric risk of mortality (PRISM), pediatric sequential organ failure assessment (pSOFA), pediatric logistic organ dysfunction-2 (PELOD-2), and pediatric multiple organ dysfunction syndrome (pMODS) scores were excluded.

Related Conditions & MeSH terms

• Critical Illness

Locations

Country	Name	City	State
Egypt	Sohag faculty of medicine	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (2)

Jo YH, Kim K, Lee JH, Kang C, Kim T, Park HM, Kang KW, Kim J, Rhee JE. Red cell distribution width is a prognostic factor in severe sepsis and septic shock. Am J Emerg Med. 2013 Mar;31(3):545-8. doi: 10.1016/j.ajem.2012.10.017. Epub 2013 Feb 4. — View Citation

Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005 Mar 10;352(10):1011-23. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	duration of hospital admission	in days	6 months