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NCT04097210 Clinical Trial

Decision-making - the Benefit of Bedside CRP Within Ambulance Care

Critical Illness Clinical Trial

— Q-CRP  

Official title:
When Triage is Insufficient - the Benefit of Bedside CRP Within Ambulance Care

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04097210
Other study ID # HUS 329/13/3/02/2015
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2016
Est. completion date June 1, 2021

Study information
Verified date November 2018
Source Helsinki University Central Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Patients with degreased (DGC) for ambiguous reasons receive low triage priority. Their death risk is triple. Tools are needed to identify the critically ill patients from this group. The triage used today is not effective. The bedside point-of-care measurements are CRP, lactate acid and suPAR (Soluble Urokinase Plasminogen Activator Receptor). Elevated values associate with the probability of critical illness and predict a risk of death.

Description:

Purpose: To improve identification and proper prioritization of patients with non-specific symptoms prehospitally, we intend to investigate whether Q-CRP, a rapid test for CRP, correlates with time-critical states in the above-mentioned patient group alone or together with CRP, lactate and suPAR. The primary endpoint is need for hospital care. Material: Patients over 18 years who exhibit non-specific symptoms and transported to the emergency room. Method: In patients with unspecified conditions, defined according to the inclusion template, a venous blood sample was taken prehospitally at the scene by the EMS. Analysis: Significance tests and regression analyzes with 95% CI were used. The diagnostic accuracy of Q-CRP, lactate, suPAR and combinations thereof were compared with optimal boundary values.

Recruitment information / eligibility
Status Completed
Enrollment 110
Est. completion date June 1, 2021
Est. primary completion date June 1, 2021
Accepts healthy volunteers
Gender All
Age group 16 Years to 104 Years
Eligibility Inclusion Criteria: - Patients over 18 years who exhibit non-specific symptoms and transported to the emergency room. Exclusion Criteria: - Abnormal vitals

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• POC

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Helsinki University Central Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary Number of patients with high suPAR level A high suPAR level, e.g. above 6 ng/ml 24 hours
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