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Citrate Anticoagulation for Postdilution Hemofiltration — CIPOHA  

Critical Illness Clinical Trial

Official title:
Citrate Anticoagulation for Postdilution Hemofiltration

Clinical Trial Summary

This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.

Clinical Trial Description

Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects.

We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol.

We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03969966
Study type Observational
Source Heinrich-Heine University, Duesseldorf
Contact
Status Recruiting
Phase
Start date January 14, 2019
Completion date July 31, 2021
View Details
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