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Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis

Critical Illness Clinical Trial

Official title:
Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis

Clinical Trial Summary

WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine & ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset

Clinical Trial Description

First, the investigators will document exposure to meropenem in plasma and epithelial lining fluid. Moreover excretion in urine will be documented. Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed. Finally in a small subset of ECMO patients PK exposure will be explored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03560557
Study type Observational
Source Universitaire Ziekenhuizen Leuven
Contact
Status Completed
Phase
Start date August 2012
Completion date October 2017
View Details
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